Auriculotemporal's syndrome in three siblings and literature review

The skin is one of the target organs that are most often involved in food hypersensitivity reactions. Clinical manifestations of food hypersensitivity in the skin range from symptoms of atopic dermatitis, urticaria, angioedema to dermatitis herpetiformis, and a masquerader of food allergy, the Frey’s syndrome. All present with typical skin manifestations of their foodallergic reactions. Three cases of Frey’s syndrome (auriculotemporal) are presented in three children from the same family: two girls and one boy. The patients presented with a history of facial erythema in cheeks after eating different foods. Food radioallergosorbant (RAST) and percutaneous skin testing were, both, negative. Skin rash was reproduced in the clinic after oral challenge.